Are 25-hydroxy calcifediol biologically active?

25-Hydroxy calcifediol, also known medically as cholecalciferol, is similar to vitamin D3 by adding a hydroxyl group to the 25-position carbon atom of the vitamin D3 molecule, following a series of biochemical reactions in the body.25-hydroxy calcifediol is obtained by the hydroxylation of the 25-hydroxylase enzyme in the mitochondria of the hepatocytes. So, what is the difference between 25-Hydroxy calcifediol and vitamin D3?

Vitamin D3 is a precursor to the active metabolite and is not biologically active, while 25-Hydroxy calcifediol is. In the human body, 25-hydroxy calcifediol is stored in the liver, while vitamin D3 is stored in the liver, fat, plasma and muscle. 25- Hydroxy calcifediol is easier to absorb than vitamin D3 and can be absorbed directly from the intestine into the bloodstream. In terms of absorption, 25-Hydroxy calcifediol absorbs at a higher rate than vitamin D3 and can be converted faster and more efficiently, bypassing the liver. 25- Hydroxy Calcifediol Is a short metabolic process that promotes the absorption of calcium.

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