What is the role of 3,4-dihydroxybenzoic acid in oxidative damage?

3,4-dihydroxybenzoic acid is an organic acid, originating from the leaves of fern, Holly and other plants as well as nuts, vegetables and other food, often used in medicine, food, chemical and other fields, can play a certain antibacterial effect on Escherichia coli, pseudomonas aeruginosa, Shigella, Bacillus subtilis, staphylococcus aureus and so on.

The 3,4-dihydroxybenzoic acid we see in the market is generally a white to brown crystalline powder, which changes color if exposed to air, breaks down in boiling water and releases carbon dioxide. Aqueous solutions of 3,4-dihydroxybenzoic acid turn green in the presence of ferric chloride and red in the presence of sodium bicarbonate.

3,4-dihydroxybenzoic acid is the precursor of synthesis of complex molecules such as anthocyanin and has many biological activities.

It is found that heat treatment of 3,4-dihydroxybenzoic acid does not affect its antibacterial activity. If it is added to muscle food, it can not only eliminate campylobacter contamination, but also develop lipid oxidation.

3,4-dihydroxybenzoic acid can promote the apoptosis of cancer cells such as liver, lung, breast and cervix, and play an important role in delaying the infiltration and metabolism of tumor cells.

3,4-dihydroxybenzoic acid has a protective or blocking effect on oxidative damage and can reduce oxidative stress in vivo. It has also been found that 3,4-dihydroxybenzoic acid can reduce the contents of glutathione, catalase, glutathione peroxidase and superoxide dismutase, thus alleviating the necrosis or bleeding of heart tissue.

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