Why does a lack of nicotinamide cause pellagra?

Nicotinamide is widely found in animal meat, liver, kidney, peanut and rice bran. It is a component of coenzyme nicotinamide adenine dinucleotide (NAD) and NAD phosphate. It is also a form of vitamin B3, which plays an important role in the metabolism of protein, carbohydrate and fat.

Nicotinamide can play an important role in cell physiology by promoting NAD+ REDOX homeostasis and providing NAD+ as a class of enzymes that catalyze non-redox reactions. It is the coenzyme of many dehydrogenases and may affect normal cell respiration and metabolism when nicotinamide is deficient, thereby causing pellagra. Nicotinamide supplementation can be used in our daily life to prevent pellagra.

Nicotinamide is an inhibitor of SIRT1, an NAD^+ -dependent histone deacetylase closely related to cell differentiation, aging, apoptosis and energy metabolism.

Nicotinamide is mainly used in clinical prevention and treatment of pellagra, stomatitis, glossotis and other diseases, and the application of nicotinamide also stems from this. By chance, people accidentally found that nicotinamide has whitening effect, so they began to study nicotinamide, and gradually found that nicotinamide can delay skin aging, inhibit melanin and whiten skin.

For now, nicotinamide, as a multifunctional ingredient, is good for skin care and hair health. In terms of skin care, it can whiten and light spots, remove acne, moisturize, resist aging and repair barriers. On the one hand, it can combine with caffeine and panthenol to make hair thicker, strengthen hair and improve hair quality.

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