Why does nicotinamide reduce melanin production?

Nicotinamide is used in skin care products, which can not only delay aging but also whiten skin. As early as in the 1970s, the British first discovered that nicotinamide in the concentration of 1%~5% and the concentration of 1%~4% sunscreen agent combined into the cream or cream body, can achieve the whitening effect, The mechanism of this experiment is that nicotinamide stimulates the breakdown of 3, 5-cyclic adenylate into adenine-5-monophosphate of melanocytic hormone by activating cyclic 3, 5-nucleotide phosphodiesterase, thereby reducing melanin production.

We see in skincare ingredients of nicotinamide not just pure nicotinamide aqueous solution, generally, there will be some other substrate, especially moisturizing agent added, to promote the extension of nicotinamide absorption time, can very good absorption effect, and a lot of moisturizers itself also has good close skin sex or promoting effect, Make our skin can effectively absorb nicotinamide, achieve the whitening effect.

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