L-2-aminobutyric acid can be widely used in the field of medicine and chemical industry, mainly as an important pharmaceutical intermediate and chemical raw materials, in the pharmaceutical process, it is used as a chiral intermediate to produce chiral drugs, as well as the synthesis of various drugs, such as ethambutol hydrochloride, levetiracetam, etc..
It is known that there are many ways to obtain L-2-aminobutyric acid, which can be mainly divided into chemical method, enzymatic method and microbial fermentation method.
Chemical methods include butanoic acid reduction method, n-butyric acid halogenation reaction method, desulfurization reaction method and so on. The preparation of L-2-aminobutyric acid by chemical method is the method used earlier, developed so far, although the process is relatively mature, but large loss, high cost, environmental pollution and other shortcomings, making this method gradually eliminated.
After the production method of L-2-aminobutyric acid was improved, l-2-aminobutyric acid was synthesized by microbial fermentation. However, it was difficult to separate and purify l-2-aminobutyric acid.
In addition, there are transaminase method, nitrile hydrolase method, amidase method, amino acid oxidase method and other enzymes to prepare L-2 aminobutyric acid, but will be affected by enzyme activity, poor stability, large loss and other factors.
The industrial production method of L-2-aminobutyric acid needs to be better optimized and improved, and appropriate methods should be studied from the aspects of technology, cost and sustainable development.
