3, 5-dihydroxyamyl benzene occurs naturally in a variety of plants and is currently used as a medical intermediate in the field of medicine. In the early stage, 3, 5-dihydroxypentyl benzene could be obtained by the degradation of plant lichen. With the rapid development of production technology, more and more methods can be used to prepare 3, 5-dihydroxyamyl benzene.
Using 3, 5-dihydroxybenzoic acid as raw material, hydroxybenzoyl was acylated, chlorinated with dichlorosilane to get acyl chloride derivatives, and then reacted with organic zinc reagent to get the corresponding ketone, using hydrazine hydrate reduction to get 3, 5-dibenzoyl pentylene, after hydrolysis and deprotection, 3, 5-dihydroxypentylene was obtained.
N-hexal can also be used for the preparation of 3, 5-dihydroxypentylene, by Wittig reaction to obtain 2-octanoate ethyl ester, and ethyl acetoacetate condensation to obtain sodium salt, and then reaction with cuprous bromide to obtain diketone bromide, in DMF sequentially debromination and decarboxylation to obtain 3, 5-dihydroxyalkyl benzene.
3-nonene-2-ketone can also be used as a raw material for the preparation of 3, 5-dihydroxyamyl benzene. After the addition and condensation of dimethyl malonate, the product can be obtained in DMF. After reaction with bromine, 3, 5-dihydroxyalkylbenzene can be obtained through aromatization and decarboxylation.
The preparation methods of 3, 5-dihydroxyalkylbenzene are various, and the yield of 3, 5-dihydroxyalkylbenzene is also different.