How to prepare 3, 5-dihydroxypentyl benzene with n-hexanal?

3, 5-dihydroxypentyl benzene exists naturally in many plants and is mainly used as pharmaceutical intermediates. In the early stage, 3, 5-dihydroxypentyl benzene was obtained by degrading plant lichens. With the rapid development of production technology, more and more methods can be used to prepare 3, 5-dihydroxypentyl benzene.

Taking 3, 5-dihydroxybenzoic acid as raw material, it was hydroxylated by benzoyl and chlorinated with dichlorosulfoxide to obtain acyl chloride derivative. Then, it reacted with organic zinc reagent to obtain corresponding ketone. 3, 5-dihydroxybenzoic acid was reduced by hydrazine hydrate to obtain 3, 5-dihydroxypentyl benzene.

N-hexanal can also be used as raw material to prepare 3, 5-dihydroxypentylene, Wittig reaction to get 2-octenoate ethyl ester, addition and condensation with ethyl acetoacetate to get sodium salt, and then react with cuprous bromide to get dione bromide, decarboxylation of dione bromide in DMF. The 3, 5-dihydroxypentyl benzene was obtained.

3, 5-dihydroxypentyl benzene can also be obtained by the addition and condensation reaction of 3-nonene-2-ketone with dimethyl malonate as raw material. The product can be obtained by the reaction with bromine, aromatization and decarboxylation.

The preparation methods of 3, 5-dihydroxy alkylbenzene are various, and the yield is also different.

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