How to prepare hydroxytyrosol by physical extraction?

Hydroxytyrosol is a long-used ingredient in medicine, cosmetics, daily chemical products and other fields, which can play an important role in antibacterial, anti-inflammatory, anti-cancer and so on.

Hydroxytyrosol can be obtained by catalytic hydrolysis of olive oil waste by enzymes or acids. On the other hand, hydroxytyrosol can also be prepared by chemical synthesis.

There are a variety of chemical synthesis methods for hydroxytyrosol, such as using 3, 4-dihydroxyphenylacetic acid as raw material to get hydroxytyrosol through reduction, or converting tyrosol or phenylethanol to hydroxytyrosol through biological catalysis or chemical methods. This method can only be used in the laboratory due to the limited raw materials and reaction. There are other ways to synthesize hydroxytyrosol using catechol and glyoxylic acid as raw materials. What is a more environmentally friendly, safe, economical and convenient way to prepare hydroxytyrosol?

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