What are the methods for preparing L-2-aminobutyric acid?

L-2-aminobutyric acid is an unnatural chiral α -amino acid, molecular formula C4H9NO2, molecular weight 103.12, CAS No. 1492-24-6, EINECS No. 216-083.L-2-aminobutyric acid can be used to synthesize levetiracetam, ethambutol and other drugs as raw material in the medical field.

There are many ways to prepare L-2-aminobutyric acid, such as transaminase method, which is currently the main method used to produce L-2-aminobutyric acid. Early preparation of L – 2 aminobutyric acid, glutamate and keto acid as raw material, under the action of amino acid transaminase L – 2 aminobutyric acid, can be obtained by this method the yield is low, then L – threonine as raw material, adopting three production L – 2 aminobutyric acid enzyme system, the method of low yield and produce influence on the purification products are by-products. Amino acid oxidase method, which is a D – amino acid oxidase, under the action of metal catalysts, the preparation of L – 2 aminobutyric acid method, the cost is higher, the method also does not apply to industrial production, in addition, there are amino acid enzymatic, dehydrogenation enzyme, etc., on the preparation methods have some limitation or the high cost of reason.

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