What is the use of L-2-aminobutyric acid? L-2 AMinobutyric acid is an important pharmaceutical intermediate and chemical raw material, widely used in the field of medicine and the chemical industry, in the process of pharmaceutical, L-2 aminobutyric acid as a chiral intermediate for the production of chiral drugs, but also can be synthesized ethambutol hydrochloride, levetiracetam, and other drugs.
How do we get L-2-aminobutyric acid? There are many ways to obtain L-2-aminobutyric acid, which can be divided into chemical, enzymatic, and microbial fermentation methods.
Chemical methods include the butanoic acid reduction method, n-butyric acid halogenation reaction method, desulfurization reaction method, and so on. The chemical method is the earliest method to prepare L-2 aminobutyric acid, which has been developed so far. It has the advantages of a relatively mature process, but it also has the disadvantages of a large loss, high cost, and environmental pollution, so this method is gradually eliminated.
After the improvement of the production method of L-2 aminobutyric acid, the microbial fermentation method was used to synthesize L-2 aminobutyric acid, but the process is complicated and the separation and purification are difficult.
In addition, there are many other enzymatic methods to prepare L-2 aminobutyric acids, such as transaminase, nitrile hydrolase, amidase, amino acid oxidase, etc., but it will be affected by many factors such as enzyme activity, poor stability, and high loss.
The industrial production method of L-2 AMinobutyric acid needs to be better optimized and improved, and suitable methods should be studied from the aspects of technology, cost, and sustainable development.