3,4-Dihydroxybenzolic Acid is a natural phenolic compound found in many edible and medicinal plants, that is why it has a common name as Protocatechuic Acid. It may exist as ester form naturally.

Basic Information

Synonym: Ethyl 3,4-dihydroxybenzoate
Ethyl protocatechuate
3,4-Dihydroxybenzoic Acid Ethyl Ester
CAS No.: 3943-89-3
Formula: C9H10O4
Molecular Weight: 182.17 g/mol
Appearance: White to off-white powder.


1、Has anti-oxidant effect

2、Inhibit prolyl hydroxylase activity


  • This substance or its ester form (Methyl 3,4-Dihydroxy Benzoate, Ethyl 3,4-Dihydroxy Benzoate) is an important key starting material (SM) of Active Pharmaecutical Ingredients (APIs) manufacturing including Gefitinib, Icotinib, Erlotinib, Roflumilast, Itopride, Ethamivan, Mebeverine, Tarceva etc.
  • Ethyl ester of 3,4-Dihydroxybenzoic Acid is approved and listed as FOOD ADDITIVE with sub-classification as antioxidiant by JEFCA/WHO.
  • It is important intermediate good to the development of chemcial industry.

Specifications Sheet

Product name

Article Number Standard Specification
Ethyl 3,4-dinhydroxybenzoate VBL-GC-017 99% Min by HPLC


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