What processes are needed to refine 3,4-dihydroxybenzoic acid?

3,4-dihydroxybenzoic acid is the metabolic product of polyphenols, which belongs to phenolic acids. It is mainly used as pharmaceutical intermediates, dyes, and analytical reagents and is widely used in pharmaceuticals, cosmetics, dyes, chemical industries, and other industries.

There are many ways to make 3,4-dihydroxybenzoic acid, such as the leaves of the plant as raw material after the raw material screening, impurity removal, pretreatment, extraction, drying, and other processes to get fine powder, pulverized fine powder over 70 sieves, take 2 grams as raw material, under certain technological conditions, to anhydrous ethanol as extractor extract, To obtain the corresponding extract, filter the extract, remove the pharmaceutical residue, and recycle the ethanol, 3,4-dihydroxybenzoic acid can be obtained.

What if you want to get refined 3,4-dihydroxybenzoic acid? Take 3,4-dihydroxybenzoic acid crude products as raw materials, add 50ml ethanol and 3ml 0.1mol/L hydrochloric acid, gently shake to dissolve, and put in the clean liquid separation funnel, use 0.1mol/L sodium hydroxide solution for extraction, and repeated extraction three times, 50ml each time. Then the extracted sodium hydroxide solution is washed with 10ml diethyl ether, and the PH value is adjusted to neutral after combining with the ether solution, and then evaporated and dried to make refined 3,4-dihydroxybenzoic acid, the appearance of white powder crystals.

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