Nicotinamide, as a medicinal ingredient, has high safety and is also a basic vitamin supplement in clinical dermatology treatment, which is widely used in the treatment of photosensitive dermatitis and acne. Recent studies have proved that nicotinamide is also effective in inhibiting melanin deposition, anti-inflammatory, and other aspects.
It has become a common understanding to avoid skin darkening with sunscreen. However, the direct cause of skin darkening is the uptake of melanin particles by keratinocytes. The whitening effect of nicotinamide is to inhibit the transport of melanocytes and the uptake of melanin particles by keratinocytes. It has been reported that nicotinamide inhibits the transport system of melanosomes by 35% to 68%. Clinical trials have shown that skin care products containing nicotinamide can reduce the number and range of human skin stains, and long-term appropriate use of skin care products containing nicotinamide can promote the fading of stains, improve the skin condition, and achieve the effect of whitening skin.