L-2-aminobutyric acid (L-2-AMinobutyric acid) is an important pharmaceutical intermediate and chemical raw material, which has been widely used in the pharmaceutical field. For example, ethylaminobutol niacin and levetiracetam are all used in L-2-aminobutyric acid.
It is understood that the L – 2 aminobutyric acid production methods are various, mainly can be divided into chemical, enzymatic and microbial fermentation, chemical method and include the butanone acid reduction method and n-butyric acid halogenated reaction method, and the desulfurization reaction method, USES the chemical preparation of L – 2 aminobutyric acid started early, therefore, the preparation technology is relatively mature, However, large losses, high costs and environmental pollution are also inevitable disadvantages, which are not beneficial to industrial production.
The production method of L-2-aminobutyric acid was improved, and l-2-aminobutyric acid was synthesized by microbial fermentation, which was more complicated and difficult to separate and purify. The preparation of L-2-aminobutyric acid by transaminase method, nitrile hydrolase method, amidase method, amino acid oxidase method and other enzymes will be affected by a variety of factors, such as enzyme activity, poor stability, not easy to reuse, etc.
The method of industrial production of L-2-aminobutyric acid needs to be optimized and improved, and the appropriate method should be studied from the aspects of technology, cost and sustainable development.
